Grant Collaborations

C-COPE addresses a critical gap in personalized multimorbidity care: the sharp, short-term rise in cardiovascular disease (CVD) events following acute exacerbations of chronic obstructive pulmonary disease (AECOPD). Evidence shows that for patients with COPD and established CVD, the first 1–7 days after an AECOPD episode constitute a peak window of preventable cardiovascular risk, with increased incidence of myocardial infarction, heart-failure decompensation, arrhythmias, stroke, hospitalization, and early mortality. Current care pathways remain largely reactive, identifying deterioration only after symptom escalation or emergency presentation.

C-COPE aims to close this gap through a personalized, multimodal digital monitoring and early-warning system for outpatient and home use that predicts and mitigates cardiovascular deterioration triggered by AECOPD. The project will evaluate an integrated solution combining home lung-function monitoring with exhaled carbon monoxide, CE-marked cardio-respiratory remote monitoring via a wearable wristband with environmental data access, wrist-based ECG for heart rate and rhythm assessment including atrial fibrillation detection, and an explainable prediction platform integrating sensor data, patient-reported outcomes, environmental exposures, and clinical history. Earlier detection of pre-symptomatic physiological changes enables timely clinical review during the highest-risk period, supporting proactive management of COPD–CVD multimorbidity.

Testing will take place in real-world outpatient and home-monitoring settings across Sweden and Türkiye. Expected outcomes include validated predictors of AECOPD-related cardiovascular vulnerability, demonstrated feasibility of the integrated solution, improved patient engagement, and implementation-ready evidence for personalized early-warning systems in COPD–CVD care pathways.